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Dermapen Cryo


Dermapen World offers the Dermapen Cryo, a portable Cryotherapy machine.


Another member of the Dermapen™ Family is the Dermapen Cryo™, which allows users to remove unsightly skin lesions in a matter of seconds. The device uses a very precise jet of highly compressed liquefied nitrous oxide (N2O) to destroy benign lesions, such as warts, skin tags, and age spots. The Cryo™ freezes the lesion’s inter-cellular fluid, forming ice crystals, which subsequently rupture the cell membrane, destroying the cell. In practice, the Dermapen Cryo™ is able to penetrate up to 1 mm per 5 seconds of application, making it an extremely versatile machine, treating anything from extremely superficial sun spots, to lesions up to 5 mm in depth.

The high precision applicator tips allow for a very targeted treatment, ensuring that only the lesion is being treated, and not the healthy tissue around it. This helps to greatly reduce the risk of post-treatment hypo-pigmentation, and makes the Dermapen Cryo™ safe for all areas of the face and body, even near the eyes.

Dermapen Cryo - Dermapenworld

The Dermapen Cryo™ kit includes two applicator tips — one for smaller and one for larger target sites (with treatable lesions varying from 1 mm to 10 mm in diameter). No matter the size of the lesion, the treatments are quick and effective, with patients rarely needing a repeat visit for a touch up.

The device features simple, one-button operation, and uses small N2O cartridges which are easily loaded into the device itself, making it light and portable.

The Dermapen Cryo™ does not rely on contact with the skin to be effective, meaning no messy buds, cones, or apertures. There is also no need for maintenance, no refilling canisters, and no preparation needed to use the device.

All in all, the Dermapen Cryo™ is convenient, safe, and effective, making it the the best-suited cryosurgery device for any aesthetically conscious clinic.

Contact Us to find out where to purchase the Dermapen Cryo™

Cartridges for the Dermapen Cryo™ are available for purchase in the Dermapen ProZone

Before & After

Before and After | Facial Wart - Dermapenworld

Facial Wart - After 4 Weeks

Before and After | Plantar Warts - Dermapenworld

Plantar Warts - After

Before and After | Seborrheic Keartosis - Dermapenworld

Seborrheic Keratosis - After 4 Weeks

Before and After | Wart Palm - Dermapenworld

Wart Palm - After 4 Weeks


Cryosurgery System for the removal of benign lesions
Input Power:
none, uses 8ml N2O canisters
Hand-piece 20x20x140 (mm)
Hand piece/90g, individual canisters/28g;
Treatable Lesion Depth Range:
from 0 to 6.0mm in depth
Treatable Lesion Size Range:
from 1 to 10mm in diameter

Practitioner FAQ’s

Q: Are the canisters refillable?

A:No, the canisters are single use, and should be properly disposed of after the gas supply has been exhausted. Additional canisters can be purchased from either the Dermapen™ ProZone, or from the distributor in your country.

Q: What is the maximum lesion size that can be treated?

A:The two applicator tips included in the kit are intended for small and larger lesions. Treatable lesions can vary in size between 1 mm and 10 mm in diameter, and from extremely superficial to 6 mm in depth. The treatment depth will depend on the combination of a particular applicator tip and user-controlled duration of gas release.

Q: What is the difference between liquid nitrogen and nitrous oxide?

A:Liquified nitrous oxide and liquid nitrogen are both cryogenic liquids, but they differ in their molecular composition, as well as other relevant factors. Most importantly, liquified nitrous oxide is not as cold as liquid nitrogen, and therefore presents a lesser risk of hypo-pigmentation.

Q: How is it possible to avoid hypo-pigmented spot after treatment?

A:Liquified nitrous oxide is not as cold as liquid nitrogen, so for one, the risk of destabilizing melanin in the skin due to over-freezing is lower. The applicator tips of the Dermapen Cyro™ are also much more precise than those of most liquid nitrogen gun, allowing the practitioner to treat just the lesion, and not the healthy tissue around it, once again contributing to the lowered risk of post-procedure hypo-pigmentation.

Q: Can moles be treated?

A:While moles can be treated, this should only be done after a proper examination by a qualified practitioners. What may appear as a mole, could potentially be a cancerous lesion which could be adversely affected by cryotherapy.

Q: Will my patients need a follow up session?

A:A follow up visit is recommended after 2 to 4 weeks to confirm that all pathological tissue has disappeared or if a follow up treatment is necessary.

Q: What about my darker skin patients, is hypo-pigmentation risk higher?

A:While the risk of hypo-pigmentation is always higher in darker skin, there are precautions that can be taken. Repeated short freezing cycles at two-week intervals are recommended for patients with a darker skin type.

Q: How much is the Dermapen Cyro™?

A:Please contact us to either purchase or get in contact with a distributor in your country.

If you have any other questions or think something is missing from this section, please contact us!

Patient FAQ’s

Q: How safe is cryotherapy?

A:Cryotherapy is a relatively low-risk procedure. The Dermapen Cyro™ delivers N2O directly to the lesion, and not the healthy surrounding tissue. The Dermapen Cyro™ is both CE and FDA registered.

Q: How long are Dermapen Cyro™ treatments?

A:The penetration rate of freezing with the Dermapen Cyro™ is approximately 1mm per 5 seconds, with a maximum freezing depth of 3 to 6 mm depending on the used applicator. The duration of the treatment time will depend on the surface area and the thickness of the tissue being treated. Upon the clinical evaluation of the thickness of the lesion, the operator will choose an application time from 1 to 30 seconds.

Q: Is the treatment painful?

A:There will be a pain sensation similar to a ballpoint pen being pushed onto the skin when the nitrous oxide reaches the bottom of the lesion. There might be a little residual stinging for a few minutes after treatment. Occasionally a blister might form and persist for a few hours.

Q: Will there be a follow up session?

A:A follow up visit is recommended after 2 to 4 weeks to confirm that all pathological tissue has disappeared or if a follow up treatment is necessary.

Q: What if I have darker skin?

A:Repeated short freezing cycles of 3 to 6 seconds at two-week intervals are recommended if you have a darker skin type.

Q: Are there any side effects?

A:Dermapen Cyro™ treatments are relatively low risk. There are a few side effects that may occur as a result of treatment, including:

  • Pigmentary changes (hypo-pigmentation and hyper-pigmentation)
  • Nerve damage (particularly in areas where nerves lie close to the surface of the skin, on fingers, wrist, area behind the ear)
  • Shards of frozen ice (minor shards of frozen ice may blow out, that will thaw on contact with healthy skin)
  • Hair follicle damage and permanent alopecia (especially when treating lesions on sites with coarse terminal hair) Any concerns should be discussed with your clinician

Any concerns should be discussed with your clinician

Q: How much will the treatment cost?

A:The cost of treatment will depend on the clinic and the size of the lesion. Make an appointment with your clinician to discuss costs and to assess your lesion.

If you have any other questions or think something is missing from this section, please Contact us to speak with a representative to find out where to purchase the Dermapen Cryo™!