Collections, Microneedling, Skin Care

Exosomes: the extraordinary regenerative force in skin rejuvenation

The beauty and aesthetic industry is undergoing a transformation. Many people who are invested in looking after their skin are searching for alternative options to cosmetic injectables. Until a few years ago, they were the only way to achieve skin rejuvenation for anti-ageing, without having to undergo the knife.

But they do very little for someone with other skin concerns such as acne, pigmentation or rosacea. So while some people may wish to preserve a youthful appearance, for others it may be important to diminish a different type of skin concern.

There have been several skin rejuvenation therapies burst onto the skin care scene which are gaining momentum and in some cases, a cult-like following.

Before we explore these, let’s take a look at Exosomes. If this is a new concept for you, trust us—they are extraordinary.

Exosomes explained

regenerative medicine

Exosomes are the by-product of cells. In simple terms, they are the bud-like component created when two cells fuse together. They are often described as microscopic bubbles or in the scientific realm as nano extracellular vesicles.

Eventually, the bud-like components break away from the fused cells, but these tiny molecules don’t fizzle away. They have an enormous role to play in skin rejuvenation.

An interesting fact about Exosomes is that although they’re not cells—which means they don’t have the ability to replicate, they are however important for tissue healing, regeneration and repair. Ok, you may be wondering, how is this possible?

Exosomes contain biomolecules including proteins, growth factors, lipids and nucleic acids such as messenger-RNA, (mRNA) and micro-RNA (miRNA). They act as messengers from stem cells to other cells. One way to imagine Exosomes at work is to think of them as little envelopes of regeneration from cell to cell.

So what this boils down to is that Exosomes have enormous benefits for the skin! They have been shown to:

  • Be an effective form of skin rejuvenation for the face, neck and hands.
  • Drastically diminish the appearance of upper lip and smile lines, crow’s feet, and neck rings.
  • Reduce the appearance of age spots and acne scars including skin depressions, and undereye hollows.
  • Improve the contour and shape of the face for a youthful appearance without surgery.

And so much more—we’ll get to these soon.

While Exosomes have created a real buzz in skin rejuvenation therapy, they are not a passing trend. Exosomes are revolutionising skin rejuvenation.

Now that you know about Exosomes, would you like to know where they come from?  

Exosomes are connected to stem cells and are retrieved from Mesenchymal Stem Cells (MSCs). Yes, that does sound very scientific, but it’s all done above-board. They are ethically harvested from consenting donors and are extracted and synthetically processed in a laboratory to strict protocols without any dilemmas or risk of corruption or cell mutation.

While the regenerative techniques of Exosome Therapy, Stem Cell Therapy and to some degree Platelet Rich Plasma Therapy are often grouped together, the truth is, they are all rather different. Let’s look at each of these.

Regenerative Medicine – 3 different therapies

Stem Cell Therapy

Stem cell therapy for skin rejuvenation utilises human stem cells to help fill in tissue and create more collagen for better looking skin. 

The reason stem cells are used for this therapy is that they have the unique ability to transform from one cell type to another. They can replace and repair damaged cells. And as they grow and divide, they heal and rejuvenate.

There is an abundance of stem cells in fat tissue therefore the process often involves collecting stem cells from fat deposits. This is done via liposuction, in which case a local anesthetic would be required.

Stem cells can also be extracted from blood. Once the extraction is complete, the stem cells need to be isolated. This may be done offsite at a lab or via a centrifuge. The stem cells are mixed with a solution of growth hormones before they are injected into the skin.

Multiple injections may be required to various areas for example the lips, chin or cheeks.  Some skin care specialists may be able to sculpt or contour for a specific finish. But this is a slow process and skin rejuvenation takes time.

While this therapy is certainly not surgery, if liposuction is involved, it may be considered a tad intrusive

The idea of stem cell therapy may sound good in theory but there is a school of thought that believes otherwise. Stem cell therapy is nothing more than a process of depositing fat to smooth out wrinkles by adding volume.

Platelet-Rich Plasma (PRP) Therapy

Platelet Rich Plasma or PRP is an effective skin rejuvenation technique that has received wide media coverage with celebrities undergoing the treatment for a youthful complexion. When combined with Dermapen it’s commonly referred to as the ‘vampire facial’ because it involves drawing blood and then smothering the skin with it. It may sound like something from a horror movie but those who undergo the procedure say they can see the benefits on their skin.  

Curious to know more about how PRP works? The process involves drawing blood from the patient, usually from the arm—just like a nurse would do for a blood test. This step alone makes it not the best approach for the faint-hearted. (But don’t worry we have a solution for you soon)!

Once drawn, a centrifuge spins the blood at high speeds to separate the PRP from the rest of the blood which is not needed and discarded. The PRP is highly concentrated, full of nutrients and growth factor proteins which are known to assist the skin to heal, particularly for wound healing.

When this skin rejuvenation trend was introduced, it was injected directly into skin of patients but it’s now common practice to do PRP therapy as part of a microneedling rejuvenation treatment. By combining this therapy with microneedling, the PRP is massaged into the skin immediately after needling. The micro-channels allow the PRP to be delivered into the deep layers for rejuvenation and healing.

While PRP with microneedling gets results for patients, it’s a messy, time-consuming and expensive process. If injected into the skin, it can also cause swelling, redness and pain at the injection sites. Some patients may be deemed ‘compromised’ for PRP which is considered an autologous procedure, while other patients may not want blood drawn.

The good news is skin rejuvenation therapy is evolving. The next level up from PRP is microneedling with Exosomes. And unlike PRP, Exosome therapy is suitable for all skin types, aesthetic conditions, skin tones and colours​.

Microneedling with Exosome Therapy

skin rejuvenation

Dermapen 4™ by DermapenWorld™ is the world’s original and most trusted microneedling device for in-clinic treatments. As a forward-thinking company always striving for excellence in scientific breakthroughs, the business has taken a giant leap into regenerative medicine. 

Partnering with the most progressive innovators in stem cell research, DermapenWorld has sourced ethically produced Exosomes. These are multipotent, highly versatile, the youngest and purest source. You can think of these as the cream of the crop!

Hailed as the birth of a regenerative force, DermapenWorld has formulated a dynamic duo as part of the award-winning Dp Dermaceuticals™ skincare range. The duo is made up of specialty serums containing Exosomes—a new non-negotiable protocol for optimising skin renewal. Let’s explore the benefits of the pair.  

MG-EXO-SKIN™ has been designed to maximise the results of in-clinic microneedling. It is the pièce de resistance and because it’s a professional solution you can only experience the benefits through an Authorised Treatment Provider.

Microneedling alone stimulates the skin’s natural healing process to produce amazing rejuvenation results. The micro-injuries signal the skin to go into repair mode. With the addition of Dp Dermaceuticals’ potent serum containing the power of Exosomes, treatments are elevated beyond skin rejuvenation to regeneration.

Exosomes are a more concentrated and diverse source of growth factors when compared to stem cells. MSC-derived exosomes deliver a skin rejuvenating focus and include 800 proteins, 1000 peptides, antioxidants and 373 lipids.

Maximise Exosome Potential

exosomes therapy

 

Here are some mind-blowing numbers:

  • When a practitioner uses MG-EXO-SKIN as a Meso-Glide during microneedling, about 7,000 Exosomes will fit onto the end of a single 33-guage needle.
  • One oscillation of a Dermapen 4 needle cartridge can deliver 112,000 Exosomes into the skin.
  • If used at top speed of 120rps, 13,440,000 Exosomes can potentially be delivered per second, with the potential for 806,400,000 Exosomes to be delivered per minute.

That’s a colossal number of Exosomes with regeneration capability being dispersed deeply and proportionately into the skin.

And while some practitioners may opt to inject Exosomes, microneedling with Dermapen 4 is a far superior technique.

With this method there are:

  • No risk of bruising at the injection site.
  • Fast recovery time so you can resume daily activities.
  • A much quicker application process—lunch-time appointments are doable.

Benefits of Exosomes in MG-EXO-SKIN

skin regeneration

 

 The Exosomes in Dp Dermaceuticals are the youngest and purest source which ensures superior quality with no corruption. The products have been clinically shown to:

  • Send signals at a cellular level to boost the natural repair process for more youthful looking skin.
  • Maximise the potential of skin regeneration without invasive techniques.
  • Stimulate the production of collagen and elastin, the building blocks of skin.
  • Promote wound healing to minimise the appearance of scars.
  • Help reduce the appearance of many common concerns such as pigmentation, rosacea and alopecia, as well as ageing.
  • Provide solutions for multiple skin conditions or concerns (not limited to anti-ageing).

And while MG-EXO-SKIN’s star ingredient is the Exosome, the combination of other actives all contribute to improving skin.

HylaFuse™ is Dp Dermaceuticals patented version of Hyaluronic Acid (HA). This incredible, triple molecular-weighted formula is absorbed 150% more effectively into the skin than other forms of HA allowing intense nourishment and hydration. 

Zinc PCA and Panthenol are other key ingredients. They are known to support wound healing while the Calphasomes™ (Calcium Hydroxylapatite) delivery system ensures all actives are penetrated deeply into skin for optimum benefits.

Exosomes at work, at home

Did you know that in between clinic treatments you can accelerate your results with at-home Microneedling and EXO-SKIN™?

Dermapen HOME™ is a microneedling system which is safe and easy to perform on yourself. While clinic appointments are generally four to six weeks apart, between these you can do microneedling on a weekly basis from the comfort of your home. And if you’re having Exosome therapy with your in-clinic microneedling then EXO-SKIN is your at-home, non-negotiable counterpart.

Just like MG-EXO-SKIN, EXO-SKIN contains powerful Exosomes with the addition of key ingredients. Niacinamide for its anti-inflammatory properties, Poly-Peptides to activate collagen and Copper Peptides for wound healing and repair—to name a few.

Cindy: My experience with Exosomes

“I cannot stress enough how EXO-SKIN has been a game-changer for me.

I first began using it as a post-serum for DIY microneedling on my face, down my neck and décolleté. I saw results almost instantly. I noticed my skin become remarkably tighter and the lines from ageing virtually disappeared. I now religiously use EXO-SKIN as part of my twice-daily skincare routine.

I recently caught up with my closest girlfriends and they noticed how youthful my skin was looking. They were convinced I’d undergone a facelift! I had no choice but to reveal my secret weapon—the regenerative power of Exosomes.”

Experience Exosomes – the DermapenWorld difference

exosomes in skincare

 

While MG-EXO-SKIN and EXO-SKIN are two amazing products, all Dp Dermaceuticals have been formulated to help you get the best out of your skin.

Whether you wish to enrich your skin’s quality from head to toe, or a specific area—your face, the delicate skin around the eyes, neck, décolleté or hands, learn about Dp Dermaceuticals.

If you are a professional and wish to learn how to become a DermapenWorld Authorised Treatment Provider, click here.

If you’re already an ATP, contact your local distributor to find out more about MG-EXO-SKIN and EXO-SKIN.