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Induce, Repair, Rejuvenate: A Dermatologist’s Comprehensive Approach to Skin Regeneration

In this session of our Global Webinar Series, we sit down with world-reowned dermatologist Dr Iren Bermejo (Argentina). With over 40 years of medical experience and 15 years specialising in microneedling, Dr Bermejo shares how she transitioned from traditional techniques to the advanced precision of the Dermapen 4®

This video highlights key insights discussed, including:

  • Patient Cases: Explore valuable Dermapen 4® case studies for acne, ageing and alopecia.

  • The ST (Scar Treatment) Protocol: How to use the specialised 3mm depth setting to break down deep fibrosis.

  • Accelerated Trichology: The science of combining Dermapen 4® with EXO-GROW™ can show fast and effective results.

  • Active Acne Management: Why Dr Bermejo treats active acne with microneedling while regulating the skin’s microbiota.

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In the latest DermapenWorld webinar, Dr Irene Bermejo offers a masterclass in the versatility of the Dermapen 4®. Her approach moves beyond simple "collagen induction" into a sophisticated realm of regeneration. By understanding the relationship between mechanical injury and the delivery of bioactive agents, practitioners can address some of the most challenging challenges in dermatology.

  • Dr Bermejo emphasises that the transition to Dermapen 4® was a significant "upgrade" for her practice. Unlike older devices or manual rollers, the 90-degree vertical entry ensures the needle enters and exits the skin without tearing. This reduces trauma and inflammation, enabling faster recovery. She cites the work of pioneers such as Dr Desmond Fernandes, noting that the goal is to trigger a massive response through thousands of micro-injuries, which the body repairs much more efficiently than a single, large-scale injury.

  • A standout feature of the webinar is the discussion on the ST (Scar Treatment) setting. For deep surgical scars, keloids, and burn tissue, Dr Bermejo utilises the device’s ability to reach 3mm depths.

    Crucially, the Dermapen 4®’s ST mode automatically reduces the motor speed to one-third. This allows the needles to penetrate dense, fibrotic tissue with absolute vertical accuracy and power. Dr Bermejo presented a case of a patient with a 15-year-old burn scar on the chest; by using the ST setting every 15 days, the team achieved dramatic remodelling and softening of the tissue in just three months—a result the patient had been told was impossible.

  • One of the most exciting applications discussed is the use of EXO-GROW™ (Exosomes-based hair collection) for hair loss.

    • HSP 70 Induction: The mechanical action of the Dermapen 4 expresses the HSP 70 protein, which stimulates the stem cells in the hair follicle.

    • The Exosome Advantage: By delivering exosomes to a depth of 1.0mm to 1.5mm, Dr Bermejo has shortened the "wait time" for results. Where traditional topical treatments take 8 to 10 months to show change, her Dermapen 4® protocols show visible improvements in hair density and quality in just 6 to 10 weeks.

  • Dr Bermejo challenges the traditional view that microneedling should be avoided in active acne. By combining the treatment with a functional medicine approach (focusing on the patient’s internal inflammation and gut health), she uses Dermapen 4® to:

    • Cleanse and eliminate blackheads before they become pustules.

    • Deliver the Dp Dermaceuticals MG-Collection™ to hydrate the skin of patients taking oral prescription medication, preventing the painful dryness and cracking often associated with the medication.

    • Regulate the skin's microbiota without relying solely on local antibiotics.

  • Practitioners can take a cue from Dr Bermejo’s signature technique: not wiping away the blood. During a procedure, when pinpoint bleeding occurs, she rubs the blood back into the puncture channels along with the active substances (like Dp Dermaceuticals™ EXO-SKIN or MG-Collection).

    This creates a "Triple Treatment" effect:

    1. Mechanical Stimulation (The needle injury).

    2. Exogenous Drug Delivery (The applied actives).

    3. Endogenous Growth Factors (The patient’s own platelets released in the blood).

Dr Irene Bermejo’s 40 years of experience culminate in a simple message: the Dermapen 4® is a versatile, cost-effective ally for any clinic. Whether treating dark skin types (where lasers pose a risk) or deep-seated surgical scars, the combination of digital precision and biological synergy allows practitioners to achieve "extraordinary results" that truly change patients' lives.

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